{"id":64817,"date":"2025-12-25T09:53:46","date_gmt":"2025-12-25T08:53:46","guid":{"rendered":"https:\/\/www.parkinson-hotline.com\/?page_id=64817"},"modified":"2026-03-06T04:11:36","modified_gmt":"2026-03-06T03:11:36","slug":"causes","status":"publish","type":"page","link":"https:\/\/www.parkinson-hotline.com\/en\/ursachen\/","title":{"rendered":"Parkinson's disease"},"content":{"rendered":"
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"Image-Parkinson-01\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t
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Understanding Parkinson's<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
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Causes of Parkinson's disease<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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The Parkinson's disease<\/strong> is realized by the Failure of a specific group of nerve cells in the brain<\/strong> caused. These cells are responsible for the production of the neurotransmitter Dopamine<\/strong> responsible. Dopamine<\/strong> is crucial for Fluid, coordinated movements<\/strong>, which Regulation of muscle tension<\/strong> and for the Overall motor skills<\/strong>. If the amount of dopamine drops, the movement disorders typical of Parkinson's occur. The causal mechanisms<\/strong>, that lead to a standstill in dopamine production are not yet fully clarified<\/strong>.<\/p>

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The most common form<\/strong> of the disease is the idiopathic Parkinson's disease<\/strong>, where No clear cause<\/strong> can be determined. This form is used by the Parkinsonism<\/strong> in which the symptoms are limited to concrete triggers<\/strong> such as medication or other illnesses. Genetic influences<\/strong> are considered to be a contributing factor, but so far no single gene<\/strong> which is directly responsible for the development of idiopathic Parkinson's disease.

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Research shows that Nerve cell damage and dopamine loss begin years before the first symptoms appear<\/strong>. Only when a significant part of the dopaminergic system is impaired - estimates are around 80 % Dopamine loss in the striatum<\/strong> the symptoms become clinically noticeable. The period between the onset of neurodegenerative processes and the visible onset of the disease is currently estimated at around five years<\/strong> estimated.

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Some sufferers bring the onset of the disease with them traumatic events<\/strong> such as accidents, operations or strong emotional stress. However, neurological experts assume that such events are not the cause of Parkinson's disease<\/strong>, but possibly bring existing symptoms to light earlier<\/strong>. The vast majority of people who experience traumatic events develop No Parkinson's disease<\/strong>.

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In addition to the idiopathic form, there are also secondary Parkinson's syndromes<\/strong>, where certain medications<\/strong> the Disrupt dopamine metabolism in the brain<\/strong>. A Long-term use<\/strong> of such drugs can cause Parkinson's-like symptoms.

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Neuropathologically, Parkinson's disease is characterized by the progressive loss of dopaminergic, neuromelanin-containing nerve cells in the substantia nigra<\/strong> characterized, a central area of the Basal ganglia<\/strong>, which play a significant role in Movement control, posture and coordination<\/strong> play a role. The decisive factor for the course of the disease is not so much the pure cell loss as the resulting Breakdown of the dopaminergic nigrostriatal signaling pathway<\/strong>, which ultimately leads to the typical motor symptoms.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Symptoms of Parkinson's disease<\/h2>\t\t\t\t<\/div>\n\t\t
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Main motor symptoms

<\/strong>Tremor (trembling)<\/strong> Typically a resting tremor that begins in a limb, often a hand.

Bradykinesia<\/strong> (Everyday movements become laborious and require more time and concentration.

Rigor<\/strong> (muscle stiffness) Increased muscle tension, which can lead to pain and limited mobility<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Main non-motor symptoms<\/strong>

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